The jets joined South Korean bombers to carry out the mock attacks just two days after North Korea fired a missile over Japan.
Officials in Seoul said the exercise was designed to “strongly counter North Korea’s repeated ballistic missile tests and development of nuclear weapons.”
The US planes reportedly took off from the country’s overseas territory of Guam, which North Korean tyrant Kim Jong-un has repeatedly threatened to nuke.
A total of two US B-1B bombers and four F-35 fighters participated in the drill with South Korean F-15 fighter jets.
A statement released by KCNA – the propaganda arm of the regime – called the missile aimed at Japan its “first step” in launching a strike on Guam.
A statement said: “Noting that the current ballistic rocket launching drill like a real war is the first step of the military operation of the KPA in the Pacific and a meaningful prelude to containing Guam, advanced base of invasion.”
The United States has now responded with simulations of surgical strikes on key enemy facilities.
The move signals a full-blown conflict erupting on the peninsula is even more likely.
Pyongyang has repeatedly threatened to attack the superpower, including claiming it has the nuclear capabilities to hit the US mainland.
After the North Korea missile launch, President Donald Trump said the “US stands with Japan 100%”, saying it would go to every length to protect its ally.