Tottenham will be hoping that Harry Kane can fire them to their first Premier League win at Wembley as Bournemouth head to London on Saturday.
Kane scored 13 goals for club and country to win the Premier League player of the month as Spurs won six of their seven games in September.
But Mauricio Pochettino’s men are still winless in the League at Wembley after three games at their temporary home, and must start to match their away form with results at the national stadium to retain any title ambitions.
Tottenham have, however, won their last two games at Wembley in cup competitions, and will be hoping for a victory against Eddie Howe’s Cherries with the south coast club struggling in 19th place in the table.
Pochettino has some big calls to make as Spurs face a daunting Champions League trip to Real Madrid four days later, though Dele Alli should play against Bournemouth given he is still suspended in Europe’s elite competition.
Spurs will have Serge Aurier back in contention after the right-back served his one-game ban at Huddersfield for a red card against West Ham, though Pochettino may save him for the Bernabeu given his experience with Paris Saint-Germain.
Christian Eriksen overcame illness to help Denmark secure a World Cup playoff spot during the international break, but may be rested with Real Madrid ahead.
Mousa Dembele, Danny Rose and Erik Lamela are all back in first-team training as they step up their rehabilitation, while Victor Wanyama remains sidelined as he works on his fitness.
Bournemouth will be without Brad Smith after the defender suffered a hip muscle problem on international duty with Australia.
Scotland midfielder Ryan Fraser has picked up a hamstring injury, as did Norway forward Josh King, but neither are expected to be long-term absentees.
Defender Tyrone Mings has been out with a back problem, while forward Callum Wilson continues to step up his rehabilitation following a serious knee injury.
Tottenham starting XI: Lloris, Alderweireld, Sanchez, Vertonghen, Trippier, Winks, Dier, Davies, Son, Alli, Kane
Bournemouth starting XI: Begovic, Cook, Francis, Ake, Daniels, Stanislas, Cook, Surman, Pugh, King, Defoe