Manchester United host Tottenham in a clash of two potential Premier League champions – but both with serious injury dilemmas.
Harry Kane is the most significant absence for Spurs due to a hamstring injury, while the Londoners are also missing Victor Wanyama due to a knee problem.
For Man United, Eric Bailly and Phil Jones should return. Bailly has been injured since the international break but Jose Mourinho is hopeful that the centre-back will return at Old Trafford, with Jones set to be involved.
United midfielders Michael Carrick, Marouane Fellaini and Paul Pogba remain out through injury, as does Zlatan Ibrahimovic and Marcos Rojo.
Man United squad: De Gea, Romero, Pereira, Valencia, Darmian, Tuanzebe, Bailly, Lindelof, Jones, Smalling, Blind, Shaw, Rojo, Young, Matic, Herrera, McTominay, Mata, Lingard, Mkhitaryan, Lukaku, Rashford, Martial.
Tottenham squad: Lloris, Vorm, Gazzaniga, Rose, Davies, Walker-Peters, Alderweireld, Vertonghen, Sanchez, Foyth, Trippier, Aurier, Dier, Sissoko, Dembele, Alli, Eriksen, Son, Llorente.
Referee: Jonathan Moss
Manchester United vs Tottenham combined XI
In a huge title showdown, Manchester United play hosts to rivals Tottenham, with Jose Mourinho looking to close the gap between his second-placed side and noisy neighbours Manchester City, who occupy top spot.
In their last meeting, the last ever game at White Hart Lane, Spurs came out 2-0 victors, but United fans will be desperate to shun Tottenham fans into silence come Saturday lunchtime.
The biggest miss for Mourinho will be the injured Paul Pogba and Zlatan Ibrahimovic, as both are on the recovery from long term injury. Marouane Fellaini looks set to miss out, as does Marcos Rojo.
For Spurs, their key man Harry Kane, once, and still a Manchester United transfer target, is ruled out with a hamstring problem.
Here, we pick the best possible combined XI from those available, in a 4-2-3-1 formation.